The p53-dependent RR small subunit (p53R2) protein, a newly identified member of the ribonucleotide reductase family, plays a key role in the p53-dependent cellular response to DNA. Several recent ...

Ribonucleotide reductases (RNRs) play a crucial role in cells as the only source of the building blocks needed for DNA replication and repair. They use radical-based chemistry to catalyze the ...

Association between health-related quality of life (HRQoL) and clinical outcomes in non-metastatic castration-resistant prostate cancer (M0 CRPC): Results from the PROSPER study. This is an ASCO ...

Chemists discover how a single enzyme maintains a cell’s pool of DNA building blocks. The study sheds light on a longstanding puzzle: how a single enzyme known as ribonucleotide reductase (RNR) ...

Ribonucleotides, units of RNA, can become embedded in genomic DNA during processes such as DNA replication and repair, affecting the stability of the genome by contributing to DNA fragility and ...

Virus-Directed Enzyme Prodrug Therapy: Intratumoral Administration of a Replication-Deficient Adenovirus Encoding Nitroreductase to Patients With Resectable Liver Cancer ...

Research led by the Max Planck Institute for Biology of Aging in Cologne reports that misincorporation of ribonucleotides into mitochondrial DNA (mtDNA) initiates an inflammatory cascade. Mitochondria ...

A paper focusing on the role of co-chaperones involved in ribonucleotide reductase (RNR) activity was recently published in PLOS Genetics and made reference to StressMarq’s Mouse Anti-Yeast HSP40, ...

Cell survival depends on having a plentiful and balanced pool of the four chemical building blocks that make up DNA—the deoxyribonucleosides deoxyadenosine, deoxyguanosine, deoxycytidine, and ...

Ribonucleotides, units of RNA, can become embedded in genomic DNA during processes such as DNA replication and repair, affecting the stability of the genome by contributing to DNA fragility and ...