Nature

Transient expression of the Bcl-2 family member, A1-a, results in nuclear localization and resistance to staurosporine-induced apoptosis

A1-a is a Bcl-2 family member found primarily in hematopoietic cells. 9 Initial studies have shown that A1-a can protect cells from undergoing apoptosis in a manner similar to Bcl-2. 34 When 32Dcl3 ...
ascopubs.org

Mebendazole induces apoptosis in distinct melanoma subtypes via Bcl-2 dependent mechanism

Prognostic impact of baseline LDH on survival independent of tumor burden in advanced melanoma: Results of phase III trial of oblimersen-dacarbazine (OBL-DTIC) vs DTIC No significant financial ...
Phys.org

Structure-destabilizing mutations transform Bcl-2 from an antiapoptotic protein into a proapoptotic protein

Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. They possess Bcl-2 homology (BH) domains, which are ...
ascopubs.org

Paclitaxel in combination with AT-101 induces apoptosis via supressing Bcl-2, bcl-XL, mcl-1 proteins in human breast cancer cells.

Effect of dormant cancer cells on angiogenesis after resisting chemotherapy. Multicentric survey on dose reduction in cancer drug therapy: Detection and measurement of critical phenomena as potential ...